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one, 7.two) ]. Challenges of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of Promethazine with Codeine Oral Option with all cytochrome P450 2D6 inhibitors (eg., amiodarone, quinidine) might result in a rise in codeine plasma concentrations plus a reduce in Lively metabolite morphine plasma concentration